In order to develop a new anti-inflammatory drug for the treatment of inflammatory diseases in pediatric practice, the pharmacological activity of CelAgrip and Ibuprofen on the development of exudation induced by histamine and carrageenan was studied in prepubertal animals. It was found that both drugs exhibited almost the same degree of anti-exudative effect, which was confirmed in an additional series of experiments using a model of aseptic peritonitis induced by acetic acid. It is believed that the action of the drugs does not show a pronounced dose dependence. Considering its low toxicity and absence of side effects, the use of CelAgrip in pediatric practice is recommended for the treatment of diseases in which inflammation plays a central role in the pathogenesis.

prepubertal period, phlogogens, histamine, carrageenan, aseptic peritonitis, exudation

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