This study presents a comprehensive analysis of the stress effects induced by the presence of portholes on an aircraft fuselage using CAD/CAE tools. Portholes are integral to aircraft design for various functions, but their inclusion may compromise structural integrity. Through detailed simulations and comparative assessments, this research aims to quantify the impact of portholes on fuselage stress levels, ultimately contributing to enhanced aircraft safety and structural optimization. The CAD/CAE process allows for a systematic examination of stress distributions under varying conditions, enabling a deeper understanding of the porthole's role in fuselage design.