This study presents a comparative analysis of various extraction solvents for assessing the polyphenol content in the peel and pulp of apple cultivars from Macedonia. Polyphenols, known for their antioxidant and health-promoting properties, are abundant in apples and contribute to their nutritional value. In this research, we examined the effectiveness of different solvents, including methanol, ethanol, and acetone, in extracting polyphenols from apple peel and pulp samples. The results reveal variations in polyphenol extraction yields and profiles, highlighting the significance of solvent selection for accurate polyphenol content determination.