This systematic review explores the profound and enduring influence of religion and spirituality on literature. Examining a wide range of literary works from different cultures and time periods, it investigates how religious beliefs, practices, and spiritual themes have shaped and enriched the world of literature. The analysis encompasses the use of religious symbolism, moral dilemmas, and theological concepts, shedding light on the nuanced ways in which literature reflects and engages with the spiritual dimensions of human existence. By synthesizing existing research, this review provides a comprehensive overview of the impact of religion and spirituality on the literary landscape, highlighting their enduring significance in storytelling and the human experience.