Delves into the profound impact of religion and spirituality on literary works across diverse cultures and epochs. This systematic review examines the multifaceted ways in which religious and spiritual themes, motifs, and beliefs permeate literature, shaping narratives, characters, and symbolism. Drawing upon a comprehensive analysis of scholarly literature, this review elucidates the complexities of religious and spiritual influences in literature, exploring their role in reflecting, questioning, and shaping societal norms, values, and existential inquiries. By synthesizing key findings and identifying recurrent patterns, this systematic review offers valuable insights into the enduring relationship between religion, spirituality, and literary expression.