This study investigates the anthelmintic activity of Chlorophytum borivilianum Santapau & Fernandez, a medicinal plant known for its diverse pharmacological properties, against Eisenia fetida earthworms. Anthelmintic activity was assessed through various parameters, including paralysis and mortality rates of the earthworms, as well as changes in their motility and morphology. The results indicate that Chlorophytum borivilianum possesses anthelmintic potential, suggesting its utility in the treatment of helminthic infections. These findings contribute to our understanding of the medicinal properties of Chlorophytum borivilianum and its potential role in natural anthelmintic therapies.