In the available va literature, there are isolated and isolated references to the influence of extragenital pathology and heredity on the development of delayed sexual development. Social and medical factors that provoke this pathology have not been studied, and therefore there are no recommendations for preclinical identification of children at risk of late puberty.

 Studying the influence of unfavorable factors and content on the main prognostic risk and complex, timely prevention of delayed sexual development is an urgent task.  Modern methods of treating this pathology are often ineffective.  This is due, on the one hand, to a late visit to the doctor, and on the other hand, to the availability of sufficiently effective diagnostic and treatment methods that make it possible to form reproductive health and normalize the functions of the second system: psychoemotional, endocrine, and immune.

   Delayed sexual development in adolescent girls requires further study and development of recommendations for the prognosis, diagnosis and treatment of this disease.

gender, development, girls, adolescents, immunity, endocrine system

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