Articles
| Open Access |
https://doi.org/10.55640/
MONOCYTIC CHEMOTACTIC PROTEIN-1 AND TRANSFORMING GROWTH IN PATIENTS WITH NEPHROSCLEROSIS ON THE BACKGROUND OF CHRONIC PYELONEPHRITIS RESULTS OF TESTING FACTOR-β1 URINARY EXCRETION
Shukurova Umida Polatovna , PhD, EMU UNIVERSITY head of educational and methodological departmentAbstract
Studies have confirmed the importance of renal nephrosclerosis as a pathomorphological basis of renal failure, in which proteinuria plays an important role in chronic pyelonephritis. In this case, the nephrotoxic effect of proteinuria is carried out through interstitial inflammation, which ends with the development of nephrosclerosis of the kidneys.
In addition, the processes of accumulation of extracellular matrix components, as well as apoptosis of cells of kidney tubules develop, which lead to atrophy of tubules, expansion of interstitial volume, loss of peritubular capillaries.
Keywords
monocyte chemotactic protein-1, transforming growth factor-β1, chemokine, matrix components, informative non-invasive method, profibrogenic cytokines, proteinuria, creatinine, interstitial fibrosis, nephrosclerosis, nephroprotective strategy.
References
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