Articles | Open Access | https://doi.org/10.55640/

CHARACTERISTICS OF PATHOMORPHOLOGICAL AND MORPHOFUNCTIONAL CHANGES IN THE ADRENAL GLANDS UNDER THE INFLUENCE OF LEONTOSIDE IN EXPERIMENTAL ATHEROSCLEROSIS (AN EXPERIMENTAL STUDY)

Razakov Bakhtiyor Yusufovich , Andijan State Medical Institute

Abstract

This study investigates the pathomorphological and morphofunctional changes in the adrenal glands under the influence of Leontoside in a model of experimental atherosclerosis. Atherosclerosis, a major cardiovascular condition, has widespread systemic effects, including on the adrenal glands, which are critical in regulating the body's stress response and metabolic functions. Leontoside, a glycoside compound, has been proposed to have therapeutic properties in cardiovascular diseases, but its specific effects on adrenal morphology and function have not been extensively studied. In this experimental study, we explore the alterations in adrenal tissue structure, function, and biochemical composition in atherosclerotic rats treated with Leontoside. The results provide insights into the potential effects of Leontoside on adrenal health and its broader implications in managing atherosclerosis-related changes in the endocrine system.

Keywords

Atherosclerosis, Leontoside, Adrenal Glands, Pathomorphological Changes, Morphofunctional Changes.

References

Chrysafides, J. R., et al. (2016). Endocrine dysfunction in atherosclerosis: Implications for cardiovascular health. Journal of Endocrinology, 221(1), 1-13.

Benatti, P., et al. (2015). Sympathetic nervous system involvement in atherosclerosis: A critical review. Vascular Pharmacology, 70, 27-35.

Simmons, R. M., et al. (2018). Adrenal morphologic changes in atherosclerosis: A structural perspective. Journal of Clinical Pathology, 71(9), 739-746.

Zhang, H., et al. (2017). Leontoside: A promising natural glycoside for anti-atherosclerotic therapy. Phytotherapy Research, 31(6), 897-905.

Zhou, Y., et al. (2019). The effects of Leontoside on endothelial function and oxidative stress in atherosclerosis. Journal of Cardiovascular Pharmacology, 74(4), 300-308.

Jiang, X., et al. (2017). Adrenal gland changes in cardiovascular diseases: Focus on atherosclerosis. Frontiers in Endocrinology, 8, 41.

Santoro, D., et al. (2016). Vascular congestion and changes in adrenal gland structure during atherosclerosis. Vascular Medicine, 21(5), 426-433.

Article Statistics

Downloads

Download data is not yet available.

Copyright License

Download Citations

How to Cite

CHARACTERISTICS OF PATHOMORPHOLOGICAL AND MORPHOFUNCTIONAL CHANGES IN THE ADRENAL GLANDS UNDER THE INFLUENCE OF LEONTOSIDE IN EXPERIMENTAL ATHEROSCLEROSIS (AN EXPERIMENTAL STUDY). (2025). International Journal of Medical Sciences, 5(02), 145-150. https://doi.org/10.55640/