HIV infection can significantly change the functioning of various organs and systems, including the hemostasis (blood clotting) system. HIV-infected children have various disorders, such as an increased tendency to thrombosis or, conversely, bleeding, which can lead to complications. Evaluation of the coagulogram helps in the diagnosis of these disorders.

The purpose of the work is to study the blood coagulation parameters in children with HIV infection at different clinical stages.

Materials and methods. In the course of the work, 89 children aged 4 to 18 years suffering from HIV infection were examined. The average age of the patients was 9.8 ± 0.49 years. The patients were divided into 4 main groups depending on the clinical stage of the disease.

Among these coagulation parameters, a reliable decrease in the platelet aggregation index was noted with normal platelet count, PTI, thrombin time and plasma fibrinogen.

Conclusions. Disturbances in the coagulogram in children at different clinical stages of HIV infection are represented by a decrease in the aggregation capacity of platelets, which is detected already at the initial stages of the disease.

HIV infection, coagulogram, platelets.

Bailly J, Haupt L, Joubert J, et al. Heparin-induced thrombocytopenia: an update for the COVID-19 era. S Afr Med J 2021; 111:841–8.

Durandt C, Potgieter JC, Mellet J, et al. HIV and haematopoiesis. S Afr Med J 2019; 109(8b):40–5.

De Koker A, Bird AR, Swart C, Rogerson JJ, Hilton C, Opie JJ. Establishing local reference intervals for full blood count and white blood cell differential counts in Cape Town, South Africa. S Afr Med J 2021; 111:327–32.

Herd CL, Mellet J, Mashingaidze T, Durandt C, Pepper MS. Consequences of HIV infection in the bone marrow niche. Front Immunol 2023; 14:1163012.

Joint United Nations Programme on HIV/AIDS. Global HIV and AIDS statistics —fact sheet. 2023. Available at: https://www.unaids.org/en/resources/fact-sheet. Accessed 2 November 2023.

Kyeyune R, Saathoff E, Ezeamama AE, Loscher T, Fawzi W, Guwatudde D. Prevalence and correlates of cytopenias in HIV-infected adults initiating highly active antiretroviral therapy in Uganda. BMC Infect Dis 2014; 14:496.

Mauricio J, Flor-de-Lima B, Pacheco P. Severe rifampicin-induced thrombocytopenia in a patient with miliary tuberculosis. Pulmonology 2020; 26:247–9.

Neunert C, Terrell DR, Arnold DM, et al. American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv 2019; 3:3829–66.

Novitzky N, Thomson J, Abrahams L, du Toit C, McDonald A. Thrombotic thrombocytopenic purpura in patients with retroviral infection is highly responsive to plasma infusion therapy. Br J Haematol 2005; 128:373–9.

Simba K, Mohamed Z, Opie JJ, et al. The International Prognostic Score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma. Leuk Lymphoma 2023; 64:613–20.

South African National AIDS Council. National strategic plan for HIV, TB and STIs 2023–2028. 2023. Available at: https://sanac.org.za/wp-content/uploads/ 2023/05/SANAC-NSP-2023-2028-Web-Version.pdf. Accessed 15 November 2023. 3

Tomoka T, Painschab MS, Montgomery ND, et al. A prospective description of HIV-associated multicentric Castleman disease in Malawi. Haematologica 2019; 104:e215–7.

Tsukamoto T. Hematopoietic stem/progenitor cells and the pathogenesis of HIV/ AIDS. Front Cell Infect Microbiol 2020; 10:60.

Volberding PA, Baker KR, Levine AM. Human immunodeficiency virus hematology. Hematology Am Soc Hematol Educ Program 2003; 2003:294–313.

World Health Organization (WHO). Global tuberculosis report 2022. Geneva, Switzerland: WHO; 2022.

Yarchoan R, Uldrick TS. HIV-associated cancers and related diseases. N Engl J Med 2018; 378:2145.