Tooth loss accelerates the physiological age-related atrophy of the alveolar processes and jaws in general. Tooth extraction quite often remains a traumatic procedure, leading to direct destruction and loss of bone tissue of the alveolar process and surrounding soft tissue. The morphological changes that occur after the removal of a tooth or tooth root can be reduced by using techniques aimed at preventing these changes. The effectiveness of osteoplastic materials is largely due to the presence of minerals and soft collagen fibers in their composition. In biochemical blood tests, the study of indicators reflecting metabolic processes in the bone tissue of the jaws revealed differences in the content of water-soluble proteins and peptides, as well as enzyme activity, depending on gender.

Smirnov B.B., Bakunova N.V., Barinov S.M., Goldberg M.A., Kutsev S.V., Shvorneva Yu.I. I. Effect of aging time of CaCO3 powders on sintering and properties of ceramics // Inorganic materials. - 2012. - T.48, No. 5. - P.631-636.

Bi L. Evaluation of bone regeneration, angiogenesis and hydroxyapatite conversion in critical calvarial defects in rats implanted with bioactive glass scaffolds / L. Bi, S. Jung, D. Day [et al.] // Journal of Biomedical Materials Research . Part A. - 2012. - Issue. 100 (12). - pp. 3267-3275.

Age-related changes in the jaw bones and temporomandibular jointsUrl:https://ortostom.net/content/vozrastnye-izmeneniya-helyustnyh-kostey-i-visochno-nizhnechelyustnyh-sustavovFile type:html Date of extraction:2020-10-11 15: 55:33.400087

4. LeGeros RZ, Trautz OR, Klein E, LeGeros JP. Two types of carbonate replacement in the structure of apatite // Experimentia. - 1969. - T.25. - P.5-7.

Sheikh Z. Biodegradable materials for bone restoration and tissue engineering / Z. Sheikh, S. Najib, Z. Khurshid [et al.] // Materials. - 2015. - Issue. 8(9). - pp. 5744-5794.

Torn Tonegawa, Toshiyuki Ikoma, Tomohiko Yoshioka, Nobutaka Hanagata, Junzo Tanaka Refinement of the crystal structure of type A carbonate apatite using powder X-ray diffraction // J Mater Sci. - 2010. - T.45. - P.2419-2426.

Wu G. Controlled in situ release of factor-1alpha and antimicroRNA-138 from stromal cells for on-demand regeneration of cranial bones / G. Wu, S. Feng, J. Quan [et al.] / Carbohydrate polymers. - 2018. - Issue. 182. - pp. 215-224.

Yuan H. Bone induction by porous glass ceramics from bioglass (45S5) / H. Yuan, J. D. de Bruyn, X. Zhang [et al.] // Journal of Biomedical Materials Research. - 2001. - Issue. 58(3). - pp. 270-276.

Zuhari K.J. Harvesting bone grafts from distant sites: concepts and methods / K.J. Zuhari // Oral Maxillofac. Surg. wedge. North Am. - 2010. - Issue. 22(3). - pp. 301-316.

Vasiliev A.V. Comparison of the kinetics of release of impregnated bone morphogenetic protein-2 from biopolymer matrices / A.V. Vasiliev, T.B. Bukharova, V.S. Kuznetsova [and others] // Perspective materials. 2019. No. 4. pp. 13-27.

Pavlov S. A. Study of osteogenesis markers of jaw bone tissue regenerators after implantation of osteoplastic materials: dissertation ... candidate of medical sciences. - Moscow, 2011. - 122 p.

Panin A. M. New generation of biocomposite osteoplastic materials (development, laboratory and clinical substantiation, clinical implementation). - Moscow, 2004. - 48 p.

13. Shishkin S.V. Clinical and biochemical rationale for the use of homeopathic drugs for the removal of third molars: dissertation ... candidate of medical sciences: 14.00.21 Moscow 2008.