This study investigated the impact of maternal stress on pancreatic development in rat offspring. Morphological analyses of the pancreas at various postnatal stages revealed a developmental delay and altered acinar cell development in the experimental group compared to controls. Notably, changes in both exocrine and endocrine cells were observed from the third day of the experiment in all stressed animals, including destructive changes in the mitochondria of acinocytes. Specifically, morphometric analysis showed a decrease of up to 4% in pancreatic acini diameter and an 18% reduction in acini height in the experimental group relative to controls. These hemomicrocirculatory changes, characterized by interstitial stroma swelling and cellular dystrophic changes, were most pronounced on day 14 and correlated with destabilization of acinocyte membrane structures. These findings suggest that maternal stress induces significant morphological changes in offspring pancreatic cells, potentially leading to chronic pancreatitis. The experimental design involved subjecting pregnant rats to a stress-inducing maze environment, with offspring pancreases examined histologically at 3, 7, 14, 21, and 30 days postnatal.

stress, pancreas, pancreatic lobes, acinus, morphological changes, experimental stress, postnatal ontogenesis, exocrine cells, endocrine cells, rat model, maternal health, chronic pancreatitis, histological preparation, morphometry, laboratory rats, saline solution, experimental conditions, abdominal cavity.

Niyozov, N., Axmedova, S., Nisanbaeva, A., Tolmasov, R. (2023). About Some Morphological Changes in the Pancreas in Experimental Hypothyroidism.

Niyozov, N., Axmedova, S., Usmanov, R., Mirsharopov, U., Nisanbaeva, A. (2023). Morphological Aspects of Pancreas Changes in Experimental Hypothyroidism.

Niyozov, N., Axmedova, S., Xudoybergenov, B., Sagdullaeva, M., & Nisanbaeva, A. (2023). Changes In The Pancreas Against The Background Of Experimental Hypothyroidism.

Niyozov, N. K., Akhmedova, S. M., Usmanov, R. D., Mirsharopov, U. M., & Nisanbayeva, A. U. (2023). Morphological Aspects of Pancreas Changes in Experimental Hypothyroidism. Journal of education and scientific medicine, 2(2), 27-31.

Kurbanovich N. N. et al. Reactive Changes In The Pancreas In Hypothyroidism //American Journal of Interdisciplinary Research and Development. – 2024. – Т. 25. – С. 343-347.

Niyozov N. K. et al. Morphology of the Pancreas Against the Background of Hypothyroidism // Journal of education and scientific medicine. – 2024. – Т. 1. – №. 5. – С. 47-52.

Akhmedova S. M. et al. Pancreatic morphology in hypothyroidism // International journal of artificial intelligence. – 2024. – Т. 4. – №. 09. – С. 475-479.

Raximova M. O. i dr. Fetometricheskie Pokazateli Plodov U Beremennix V Sostoyanii Gipotireoza // Orgkomitet konferensii. – 2021. – S. 143.

Kurbanovich NN i soavt. Osobennosti morfologicheskix izmeneniy podjeludochnoy jelezi // Texasskiy jurnal meditsinskix nauk. – 2023. – T. 16. – S. 79-83.

Muxamadovna A.S. i soavt. Pokazateli fetometrii ploda u beremennix v sostoyanii gipotireoza // Texasskiy jurnal meditsinskix nauk. – 2023. – T. 16. – S. 75-78.

Niyazov N. K., Nabidjanova D., Valiyeva M. Indications of morphological changes of the pancreas in experimental hypothyroidism// “International scientific conference” Innovative trends in science, practice, and education. – 2022. – Т. 1. – №. 4. – С. 16-19.

Muminov O. B., Niyozov N. K., Nisanbaeva A. U. Nauchniy meditsinskiy vestnik yugri // Nauchniy meditsinskiy vestnik yugri Uchrediteli: Xanti-Mansiyskaya gosudarstvennaya meditsinskaya akademiya. – 2021. – T. 1. – S. 141-143.

Sagatov T. A. i dr. Morfologicheskoe sostoyanie mikrosirkulyatornogo rusla i tkanevix struktur matki pri xronicheskoy intoksikatsii pestitsidom “Vigor” // Problemi nauki. – 2019. – №. 2 (38). – S. 56-60.

Sadikova Z. Sh. i dr. Sostoyanie Jenskix Polovix Organov Pri Postnatalnom Razvitii Potomstva V Usloviyax Vnutriutrobnogo Vozdeystviya Pestitsidov // Morfologiya. – 2020. – T. 157. – №. 2-3. – S. 183-183.

Kurbanovich N. N. et al. Features Of Morphological Changes in the Pancreas // Texas Journal of Medical Science. – 2023. – Т.

– С. 79-83. 16. Muhamadovna A. S. et al. Indicators of Fetometry of the Fetus in Pregnant Women in a State of Hypothyroidism // Texas Journal of Medical Science. – 2023. – Т. 16. – С. 75-78.

Niyozov N. i dr. Changes In The Pancreas Against The Background Of Experimental Hypothyroidism. – 2023.

Mukhamadovna, A. S., Khairullaevich, K., Pulatov, N. N. Q., Dinarа, K., Utkurxodjaevna, S. M. K., Urinbekovna, N. A. Morphological Characteristics of Myocardial Changes When Exposed to Pesticides.

Niyozov, N., Axmedova, S., Nisanbaeva, A. (2023). Manifestations of morphological changes in experimental diabetes mellitus.

Umerov A.A., Niyozov N.Q. Pancreatic pathologies: understanding the interplay between chronic diseases and metabolic dysfunction // Conference on the role and importance of science in the modern world. – 2025. – Т. 2. – №. 1. – С. 104-107.

Niyozov N. et al. Pancreatic pathologies: understanding the interplay between chronic diseases and metabolic dysfunction // Medical sciences art studies. – С. 104-107.