Chronic renal failure (CRF) is a systemic disease characterized by accumulation of uremic toxins, impaired microcirculation, and activation of systemic inflammation. These processes have a significant impact on periodontal tissues, enhancing inflammatory responses and leading to destruction of connective and bone tissue. This article reviews the pathophysiological mechanisms linking CRF with inflammatory periodontal diseases, including the role of uremic toxins, calcium-phosphorus imbalance, and oxidative stress. Promising therapeutic approaches, including the use of biomarkers , new-generation antioxidants, and regenerative technologies, are also discussed. This work highlights the need for an interdisciplinary approach to the diagnosis and treatment of patients with CRF to minimize negative consequences on the periodontium.

chronic renal failure, inflammatory periodontal diseases, uremic toxins, oxidative stress, biomarkers , regenerative technologies, systemic inflammation.

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