Articles | Open Access | https://doi.org/10.55640/

POPULATION FREQUENCIES AND ASSESSMENT OF THE CONTRIBUTION OF THE RS1800469 POLYMORPHISM OF THE TGFВ1 GENE TO THE PATHOGENETIC MECHANISM OF MYOPIA AMONG THE POPULATION OF THE FERGANA VALLEY

Otabek Azizbekovich Ikramov,Azizbek Fazilovich Ikramov , Andijan State Medical Institute

Abstract

In Western and East-West Asia, there is an increase in axial hyperopia among the young population in the last three decades. Which is caused by hereditary factors or pregnancy defects.

Keywords

Myopia, schoolchildren, genetic factors, polymorphism, population frequencies, visual acuity.

References

Aprelev A. E. et al. Prevalence of myopia and epidemiological factors causing its development // Russian Ophthalmological Journal. - 2022. - Vol. 15. - No. 4. - P. 144-149.

Arkhipov G. S., Zyablitskaya A. N., Ivanitskaya Yu. N. The influence of artificial illumination indicators on the incidence of myopia among schoolchildren of the Altai Republic // Organizing Committee of the Conference. - 2016. - P. 211.

Kuryazova Z. Kh., Yangieva N. R. Issues of pathogenesis and prevention of myopia (literature review) // Journal "Medicine and Innovation". - 2021. - No. 3. - P. 54-61.

Iomdina E.N., Tarutta E.P. Modern directions of fundamental research of the pathogenesis of progressive myopia // Bulletin of the Russian Academy of Medical Sciences. - 2014. - No. 3-4, V. 69. - P. 44-49.

Markosyan G.A., Tarutta E.P., Iomdina E.N., et al. Clinical, functional and biomechanical aspects of pathogenesis, diagnosis and treatment of congenital myopia: literature review and analysis of our own data. // Russian pediatric ophthalmology, 2016. -11 (3), 149-157.

Mosalev K.I., Yankovskaya S.V., Ivanov I.D. et al. Association of carriage of the rs4646994 polymorphism of the ace gene with obesity and androgen deficiency in men. Obesity and Metabolism, 2022, 19 (3), 271-279. doi: 10.14341/omet12843

Abdulfattah SY, Salman Alagely H, Abid Kathum O, Samawi FT. Association of serum level of TGF-B1 and its genetic polymorphisms (C509T and T869C) with Ischemic heart disease in Iraqi population. Hum Immunol. 2024 Sep 20;85(6):111145. doi: 10.1016/j.humimm.2024.111145.

Biler ED, Ilim O, Palamar M, Onay H, Uretmen O. TGFB1 and LAMA1 gene polymorphisms in children with high myopia. Pak J Med Sci. 2018 Mar-Apr;34(2):463-467. doi: 10.12669/pjms.342.14616.

Cao H, Zhou Q, Lan R, Røe OD, Chen X, Chen Y, Wang D. A functional polymorphism C-509T in TGF β -1 promoter contributes to susceptibility and prognosis of single atrial fibrillation in the Chinese population. PLoS One. 2014 Nov 17;9(11):e112912. doi: 10.1371/journal.pone.0112912.

Chu F. F., Yang S. K., Zeng W. L. The Influence of ACE Insertion/Deletion Gene Polymorphism on the Risk of IgA Nephropathy: A Debatable Topic. Genet Res (Camb). 2021 Nov 18;2021:3112123. doi: 10.1155/2021/3112123.

Gichkun OE, Shevchenko OP, Kurabekova RM, Mozheiko NP, Shevchenko AO. The rs1800470 Polymorphism of the TGFB1 Gene Is Associated with Myocardial Fibrosis in Heart Transplant Recipients. Acta Naturae. 2021 Oct-Dec;13(4):42-46. doi: 10.32607/actanaturae.11469.

Fawcett T. ​An introduction to ROC analysis // Pattern Recognition Letters. – 27 (2006). –861–874.

Grossberg AJ, Lei X, Xu T, Shaitelman SF, Hoffman KE, Bloom ES, Stauder MC, Tereffe W, Schlembach PJ, Woodward WA, Buchholz TA, Smith BD. Association of Transforming Growth Factor β Polymorphism C-509T With Radiation-Induced Fibrosis Among Patients With Early-Stage Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2018 Dec 1;4(12):1751-1757. doi: 10.1001/jamaoncol.2018.2583.

Article Statistics

Downloads

Download data is not yet available.

Copyright License

Download Citations

How to Cite

POPULATION FREQUENCIES AND ASSESSMENT OF THE CONTRIBUTION OF THE RS1800469 POLYMORPHISM OF THE TGFВ1 GENE TO THE PATHOGENETIC MECHANISM OF MYOPIA AMONG THE POPULATION OF THE FERGANA VALLEY. (2025). International Journal of Medical Sciences, 5(02), 494-497. https://doi.org/10.55640/