The liver is a heterogeneous tissue, the functional unit of which, the lobule— continues to baffle morphologists for more than 300 years. Surprisingly, regardless of the angle at which the liver is cut, it mostly has the same histological appearance, i.e. multiple units with a hepatic venule (also known as a central vein) surrounded in the center by about 4-6 portal areas. This phenomenon is the basis for the liver to be called having an "isotropic parenchyma," and it contributes to a mysterious, complex, three-dimensional architecture. Trying to understand three-dimensionality has helped us better understand liver function.

liver, morphology, hepatocytes, bile duct, proliferation, eosinophilic normoblasts, megakaryocytes, nuclear-cytoplasmic ratio, parenchyma.

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