The pharmacoresistant form of epilepsy (FRE) is a type of epilepsy that does not respond to traditional anti-epileptic drugs (TEA), and its correct and early diagnosis is important for improving the quality of life of patients and the treatment strategy. This article analyzes the importance of biochemical studies in the diagnosis of FRE. Biochemical parameters such as blood metabolites, neurotransmitters, antioxidant system indicators, and inflammatory markers can play an important role in the development and pathogenesis of pharmacoresistance. It was also noted that some biomarkers (glutamate, GABA, cytokines, indicators of oxidative stress) help to differentiate FRE from traditional forms of epilepsy. The results of the study show that biochemical studies in combination with clinical and neurophysiological tests allow for early detection of the pharmacoresistant form of epilepsy and individualization of treatment tactics.

epilepsy, pharmacoresistance, biochemical markers, neurotransmitters, oxidative stress, inflammation.

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