Diabetes mellitus and Parkinson's disease are among the most pressing problems of modern medicine, negatively affecting the quality of life of millions of people. While diabetes is a metabolic disease characterized primarily by elevated blood glucose levels [1], Parkinson's disease is a chronic neurodegenerative disease of the central nervous system, mainly manifested by movement disorders [2]. Recent studies have shown that there is a correlation between these two common diseases [3, 4], which raises the need for a deeper study of their pathogenesis and treatment strategies. This thesis reviews the main features of diabetes mellitus and Parkinson's disease, the evidence indicating their association, and the potential mechanisms of this association.

Diabetes, Parkinson's disease, Neurodegenerative diseases, Insulin resistance, Oxidative stress, Alpha-synuclein, Mitochondrial dysfunction

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Bharath, S., & D'Souza, M. (2019). Diabetes and Parkinson's Disease: A Review of the Association. Journal of Clinical and Diagnostic Research, 13(1), ZE01-ZE05.

de Oliveira, J. E., da Rocha, M. J., & de Carvalho, J. F. (2018). Parkinson's disease and diabetes mellitus: a systematic review and meta-analysis. Arquivos de Neuro-Psiquiatria, 76(12), 819-826.

Avogaro, A., Fadini, G. P., & de Kreutzenberg, S. V. (2018). Insulin resistance, inflammation, and oxidative stress in the pathogenesis of diabetic neuropathy. Diabetes Care, 41(Supplement 2), S116-S123.

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