Determination of the titer of antibodies against nuclear antigens is important in the diagnosis of autoimmune diseases. This test is used to diagnose various autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and other collagenoses, by detecting antibodies produced by the body's immune system against its own tissues. The clinical laboratory plays a central role in conducting tests for autoimmune diseases. Antibody titers and their specific types are determined using methods such as immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). The results of this test allow doctors to assess the patient's prognosis, determine treatment strategies, and monitor the course of the disease. Pathophysiology, on the other hand, helps to understand the mechanisms of autoimmune diseases by studying the causes and development processes of the disease. New diagnostic and therapeutic methods are developed by studying the stages of autoimmune reactions, inflammatory processes in the body, and pathological changes caused by the immune system.

Antinuclear antigen antibodies, Autoimmune diseases, Systemic lupus erythematosus (SLE), Scleroderma, Sjogren's syndrome, Mixed connective tissue disease, Dermatomyositis, Polymyositis.

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