This article is dedicated to the topic of changes in blood during pregnancy and biomarkers of pathology in the circulatory system of your heart, the importance of diagnosing and treating this disease. Heart disease is an important cause of maternal mortality in developing countries. Rheumatic heart disease is the cause of most abuse and deaths, and mitral stenosis is the most common lesion. In accordance with the purpose and objectives of the study, 110 pregnant women were examined. The results of the study showed that pregnant women with mitral stenosis show signs of systemic inflammation (increased levels of CRP, il-α), hypercoagulation (high levels of fibrinogen and d-enzyme) and impaired immune balance (decreased levels of il-10, increased IL-2). IL

pregnancy, mitral valve stenosis, inflammation, hypercoagulation, immunity.

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