Articles | Open Access | https://doi.org/10.55640/

THE ROLE OF INFLAMMATORY MARKERS IN THE EARLY DIAGNOSIS OF SEPSIS

Jamolira Bobbilarat Amuja ,

Abstract

Sepsis is a life-threatening condition resulting from the body's extreme response to infection. Early diagnosis is crucial to reduce morbidity and mortality. Inflammatory markers, such as C-reactive protein (CRP), procalcitonin (PCT), and interleukins, play a vital role in the early identification and management of sepsis. This study investigates the diagnostic value of these biomarkers in patients with suspected sepsis in intensive care units (ICUs).

Keywords

Sepsis, Procalcitonin, CRP, Interleukin-6, Inflammatory biomarkers, Early diagnosis

References

Angus, D. C., & van der Poll, T. (2013). Severe sepsis and septic shock. New England Journal of Medicine, 369(9), 840–851. https://doi.org/10.1056/NEJMra1208623

Becker, K. L., Nylen, E. S., White, J. C., Müller, B., & Snider, R. H. (2004). Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. Journal of Clinical Endocrinology & Metabolism, 89(4), 1512–1525.

Pierrakos, C., & Vincent, J. L. (2010). Sepsis biomarkers: a review. Critical Care, 14(1), R15. https://doi.org/10.1186/cc8872

Wacker, C., Prkno, A., Brunkhorst, F. M., & Schlattmann, P. (2013). Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. The Lancet Infectious Diseases, 13(5), 426–435.

Tan, M., Lu, Y., Jiang, H., & Zhang, L. (2014). The diagnostic accuracy of procalcitonin and C-reactive protein for sepsis: A systematic review and meta-analysis. Journal of Cellular Biochemistry, 115(5), 982–986.

Schuetz, P., Albrich, W., & Mueller, B. (2011). Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Medicine, 9, 107. https://doi.org/10.1186/1741-7015-9-107

Gogos, C. A., Drosou, E., Bassaris, H. P., & Skoutelis, A. (2000). Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. Journal of Infectious Diseases, 181(1), 176–180.

Meisner, M. (2014). Update on procalcitonin measurements. Annals of Laboratory Medicine, 34(4), 263–273.

Póvoa, P. (2002). C-reactive protein: a valuable marker of sepsis. Intensive Care Medicine, 28(3), 235–243.

Dellinger, R. P., Levy, M. M., Rhodes, A., et al. (2013). Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Medicine, 39(2), 165–228.

Article Statistics

Downloads

Download data is not yet available.

Copyright License

Download Citations

How to Cite

THE ROLE OF INFLAMMATORY MARKERS IN THE EARLY DIAGNOSIS OF SEPSIS. (2025). International Journal of Medical Sciences, 5(08), 65-66. https://doi.org/10.55640/