Articles | Open Access | https://doi.org/10.55640/

THE EFFECTIVENESS OF EARLY ANTIVIRAL THERAPY IN REDUCING COVID-19 SEVERITY

Jevana D, Riagup K ,

Abstract

The global outbreak of COVID-19 has led to a critical need for effective therapeutic strategies. Among these, early administration of antiviral agents such as remdesivir and molnupiravir has shown potential to reduce disease severity and improve clinical outcomes. This study investigates the clinical impact of initiating antiviral therapy during the early phase of SARS-CoV-2 infection, focusing on hospitalization rates, ICU admissions, and mortality.

Keywords

COVID-19, SARS-CoV-2, antiviral therapy, remdesivir, early treatment, clinical outcomes

References

Gottlieb, R. L., Vaca, C. E., Paredes, R., et al. (2022). Early remdesivir to prevent progression to severe COVID-19 in outpatients. New England Journal of Medicine, 386(4), 305–315. https://doi.org/10.1056/NEJMoa2116846

Jayk Bernal, A., Gomes da Silva, M. M., Musungaie, D. B., et al. (2022). Molnupiravir for oral treatment of COVID-19 in nonhospitalized patients. New England Journal of Medicine, 386(6), 509–520. https://doi.org/10.1056/NEJMoa2116044

Hammond, J., Leister-Tebbe, H., Gardner, A., et al. (2022). Oral nirmatrelvir for high-risk, nonhospitalized adults with COVID-19. New England Journal of Medicine, 386(15), 1397–1408. https://doi.org/10.1056/NEJMoa2118542

WHO Solidarity Trial Consortium. (2022). Remdesivir and three other drugs for hospitalized patients with COVID-19: Final results of the WHO Solidarity randomized trial and updated meta-analyses. The Lancet, 399(10339), 1941–1953. https://doi.org/10.1016/S0140-6736(22)00519-0

Arbel, R., Sagy, Y. W., Hoshen, M., et al. (2022). Nirmatrelvir use and severe COVID-19 outcomes during the Omicron surge. New England Journal of Medicine, 387(9), 790–798. https://doi.org/10.1056/NEJMoa2204919

Gupta, R. K., Topol, E. J. (2022). COVID-19 pandemic: The case for rapid and early antiviral treatment. Nature Reviews Microbiology, 20, 173–174. https://doi.org/10.1038/s41579-022-00685-9

Reis, G., Silva, E. A. M., Silva, D. C. M., et al. (2022). Effect of early treatment with fluvoxamine on risk of emergency care and hospitalization among patients with COVID-19. The Lancet Global Health, 10(1), e42–e51.

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THE EFFECTIVENESS OF EARLY ANTIVIRAL THERAPY IN REDUCING COVID-19 SEVERITY. (2025). International Journal of Medical Sciences, 5(08), 67-68. https://doi.org/10.55640/