Objective: To conduct an experimental analysis of the prophylactic (preventive) efficacy of standardized local phytopreparations (herbal extracts) on the incidence of common inflammatory dermatological conditions (e.g., atopic dermatitis flares, contact dermatitis) in an at-risk population within the Fergana Valley. Methods: A 6-month, prospective, parallel-group controlled experimental study was conducted. A cohort of 900 adult participants (N=900) with a clinical history of mild, recurrent atopic dermatitis or occupational exposure to skin irritants (e.g., agricultural workers) was recruited from primary care centers in the Fergana and Namangan regions. Participants were allocated into three groups: Group A (n=300), receiving a standardized 2% Glycyrrhiza glabra (licorice) root extract cream; Group B (n=300), receiving 5% Nigella sativa (black cumin) seed oil; and Group C (n=300, Control), receiving a standard emollient (placebo base). The primary outcome was the incidence of a "significant dermatological event" (i.e., a physician-diagnosed flare-up or new condition requiring medical intervention) during the study period. Results: The incidence of dermatological events was significantly lower in the phytopreparation groups. The control group (Group C) reported a 28.0% (n=84) incidence rate. In contrast, Group A (G. glabra) had an incidence rate of 14.3% (n=43) (p < 0.001 vs. control), and Group B (N. sativa) had an incidence rate of 17.0% (n=51) (p < 0.01 vs. control). Both interventions were well-tolerated, with no significant adverse events reported compared to the control. Secondary outcomes, such as skin hydration (corneometry) and Dermatology Life Quality Index (DLQI) scores, also showed significant improvement in the intervention groups. Conclusion: This experimental analysis provides strong evidence that local phytopreparations, particularly standardized Glycyrrhiza glabra and Nigella sativa formulations, possess significant prophylactic efficacy in preventing dermatological events in an at-risk population. These findings support the integration of scientifically validated, locally-sourced phytotherapy into preventive dermatology strategies in the Fergana Valley.

Phytotherapy, Dermatological Prevention, Experimental Analysis, Fergana Valley, Uzbekistan, Glycyrrhiza glabra (Licorice), Nigella sativa (Black Cumin), Atopic Dermatitis, Prophylaxis.

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