Background: Functional upper gastrointestinal (GI) disorders, presenting with chronic or recurrent symptoms such as epigastric pain, postprandial fullness, and early satiety without detectable organic lesions, are a significant clinical concern. Clinical symptom patterns combined with laboratory evaluation provide valuable insight into disease mechanisms and patient management.

Objective: To evaluate clinical and laboratory profiles of patients with functional upper GI disorders and assess correlations with demographic and psychosocial factors.

Methods: A cross-sectional study was conducted with 150 patients (60 males, 90 females) and 50 healthy controls. Demographic data, clinical symptoms, laboratory parameters (including liver enzymes, CBC, metabolic profiles, Helicobacter pylori status), and psychological assessment via the Hospital Anxiety and Depression Scale (HADS) were collected. Statistical analyses included descriptive statistics, Student’s t-test, and Fisher’s exact test (p<0.05).

Results: Epigastric pain and postprandial fullness were most common. Female patients and those aged 30–50 years reported higher symptom severity. Mild liver enzyme elevations occurred in 12% of patients; 35% were H. pylori-positive. Anxiety and depression scores correlated with symptom intensity.

Conclusion: Clinical and laboratory findings, together with demographic and psychosocial factors, influence the presentation of functional upper GI disorders. Integrating these assessments may improve diagnosis and individualized patient management.

Functional upper gastrointestinal disorders, clinical evaluation, laboratory tests, psychosocial factors, Helicobacter pylori.

Talley NJ, Ford AC. Functional Dyspepsia. New England Journal of Medicine. 2015;373:1853–1863.

Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal Disorders. Gastroenterology. 2016;150:1380–1392.

Ford AC, Marwaha A, Lim A, Moayyedi P. The epidemiology of dyspepsia. Alimentary Pharmacology & Therapeutics. 2014;40:1199–1207.

Vanheel H, Tack J. Functional Dyspepsia: Advances in Pathophysiology and Management. Gut. 2014;63:1214–1225.

Talley NJ, Walker MM, Aro P, et al. Non-ulcer dyspepsia: psychosocial factors and health care use. Gastroenterology. 2011;141:1192–1200.

Miwa H. Functional dyspepsia: pathophysiology, diagnosis and treatment. J Gastroenterol. 2012;47:1–12.

Ford AC, Lacy BE, Talley NJ. Functional dyspepsia. New England Journal of Medicine. 2017;376:2536–2546.

Drossman DA. Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Gastroenterology. 2016;150:1262–1279.

Choung RS, Locke GR, Zinsmeister AR, et al. Psychosocial distress in patients with functional dyspepsia. Alimentary Pharmacology & Therapeutics. 2007;25:365–374.

Lacy BE, Weiser K, Kennedy A, Crowell MD. Functional dyspepsia: epidemiology, pathophysiology, and treatment. Gastroenterology & Hepatology. 2013;9:203–215.