This extended study provides a detailed comparative assessment of immobilization stress, cold stress, noise-induced stress, and corticosteroid-induced stress using morphological, histological, and functional parameters. The results show that corticosteroid exposure leads to the strongest immunosuppressive changes in thymic and lymph node architecture, whereas noise stress induces only mild and reversible alterations. The integration of histological observations, quantitative scoring, and graphical analysis improves the understanding of stress-induced secondary immunodeficiency.

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