Liver cirrhosis is a chronic progressive disease accompanied by profound morphological and functional alterations of the hepatobiliary system. Hemostatic disorders represent a characteristic component of cirrhosis and include anemia, thrombocytopenia, leukopenia, and coagulopathy. Contemporary research demonstrates that the hemostatic system in cirrhosis is not in a state of complete hypocoagulation, as previously believed. Instead, a condition of “rebalanced hemostasis” develops, in which impaired production of procoagulants and anticoagulants maintains a fragile equilibrium, predisposing patients to both bleeding and thrombosis. This article summarizes current data on the mechanisms of hematological disorders, diagnostic approaches, and therapeutic strategies, including discussion of the roles of thrombopoietin, hepcidin, coagulation factors, hypersplenism, and portal hypertension. Understanding these processes is essential for optimizing patient management and guiding treatment decisions.

liver cirrhosis, anemia, thrombocytopenia, coagulopathy, rebalanced hemostasis, thrombopoietin, hypersplenism.

Tripodi, A., & Mannucci, P. M. (2021). The coagulopathy of chronic liver disease. New England Journal of Medicine, 384(2), 147–156. https://doi.org/10.1056/NEJMra2005630

Lisman, T. (2021). Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences. Blood, 137(6), 743–754. https://doi.org/10.1182/blood.2020006528

Intagliata, N. M., Northup, P. G., & Caldwell, S. H. (2023). Coagulation pathways, hemostasis, and thrombosis in liver disease. Hepatology, 78(3), 1121–1135. https://doi.org/10.1097/HEP.0000000000000370

Senzolo, M., Burra, P., & Lisman, T. (2021). Hemostasis in liver disease: From guidelines to clinical practice. Journal of Hepatology, 75(1), 120–135. https://doi.org/10.1016/j.jhep.2021.02.030

Stravitz, R. T., & Lee, W. M. (2022). Acute-on-chronic liver failure and the dysregulated hemostasis. Hepatology Communications, 6(7), 1539–1551. https://doi.org/10.1002/hep4.1960

De Pietri, L., Bianchini, M., & Montalti, R. (2022). Thromboelastography and rotational thromboelastometry in cirrhosis: clinical implications. Seminars in Thrombosis and Hemostasis, 48(5), 529–542. https://doi.org/10.1055/s-0041-1742271

Garcia-Tsao, G., & Bosch, J. (2023). Portal hypertension and its complications. New England Journal of Medicine, 388(14), 1293–1306. https://doi.org/10.1056/NEJMra2204327

Халимова, Ю. С. (2021). MORPHOFUNCTIONAL ASPECTS OF THE HUMAN BODY IN THE ABUSE OF ENERGY DRINKS. Новый день в медицине, 5(37), 208-210.

Халимова, Ю. С. (2022). МОРФОФУНКЦИОНАЛЬНЫЕ ОСОБЕННОСТИ ЯИЧНИКОВ КРЫС ПРИ ВОЗДЕЙСТВИИ КОФЕИН СОДЕРЖАЩИХ НАПИТОК. Gospodarka i Innowacje., 23, 368-374.

Salokhiddinovna, X. Y. (2023). INFLUENCE OF EXTERNAL FACTORS ON THE MALE REPRODUCTIVE SYSTEM. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 3(10), 6-13.

Халимова, Ю. С., & Шокиров, Б. С. (2022). МОРФОФУНКЦИОНАЛЬНЫЕ ООБЕННОСТИ ВНУТРЕННИХ ОРГАНОВ ПРИ ХРОНИЧЕСКОМ АЛКОГОЛИЗМЕ. Scientific progress, 3(2), 782-789.

Halimova, Y. S. (2023). Morphological Aspects of Rat Ovaries When Exposed to Caffeine Containing Drink. BEST JOURNAL OF INNOVATION IN SCIENCE, RESEARCH AND DEVELOPMENT, 2(6), 294-300.

Halimova, Y. S., Shokirov, B. S., & Khasanova, D. A. (2023). Reproduction and Viability of Female Rat Offspring When Exposed To Ethanol. Procedia of Engineering and Medical Sciences, 32-35.

Salokhiddinovna, H. Y. (2023). Morphological Features of the Human Body in Energy Drink Abuse. EUROPEAN JOURNAL OF INNOVATION IN NONFORMAL EDUCATION, 3(5), 51-53.

Халимова, Ю. С., & Шокиров, Б. С. (2022). СОВРЕМЕННЫЕ ДАННЫЕ О МОРФО-ФУНКЦИОНАЛЬНЫХ АСПЕКТОВ ЧЕЛОВЕЧЕСКОГО ОРГАНИЗМА ПРИ ЗЛОУПОТРЕБЛЕНИЕ ЭНЕРГЕТИЧЕСКИМИ НАПИТКАМИ. PEDAGOGS jurnali, 4(1), 154-161.

Halimova, Y. S. (2023). Morphofunctional Aspects of Internal Organs in Chronic Alcoholism. AMALIY VA TIBBIYOT FANLARI ILMIY JURNALI, 2(5), 83-87.