Uterine fibroids (leiomyoma) are one of the most common benign neoplasms of the female reproductive system, which have a significant impact on fertility and quality of life. Metabolic disorders, including obesity, insulin resistance, dyslipidemia, and metabolic syndrome, are becoming increasingly common among women of reproductive age and have an impact on the pathogenesis, growth, and clinical course of fibroids. This article examines modern ideas about the relationship between fibroids and metabolic disorders, analyzes the mechanisms of the influence of the metabolic background on the development of myomatous nodes, and provides current recommendations for drug, surgical, and conservative therapy with an emphasis on preserving reproductive function. Special attention is paid to a personalized approach, multidisciplinary follow-up and relapse prevention.

uterine fibroids; fertility; metabolic syndrome; insulin resistance; treatment; myomectomy; conservative therapy; hormone therapy.

Ma, Y., Weng, J., & Zhu, Y. (2024). Impact of serum lipid on recurrence of uterine fibroids: a singlecenter retrospective study. BMC Women’s Health, 24, 677. https://doi.org/10.1186/s12905-024-03530-0 BioMed Central

S. E. S., A. P., V. V., R. M., & M. B. (2024). Glycolytic reprogramming in uterine fibroids: genetic, transcriptomic, proteomic, and metabolomic insights. Genes, 16(11), 1268. https://doi.org/10.3390/genes16111268 MDPI

Ciebiera, M., et al. (2023). The etiopathogenesis of uterine leiomyomas: A review. Гинекология, 25(1), 2230. https://doi.org/10.26442/20795696.2023.1.201827 g-academy.ru

Olusi, A. M., Rabiu, K. A., OduolaOwoo, B. B., Rasheed, M. W., OduolaOwoo, L. T., & Windapo, O. B. (2024). Relationship between Metabolic Syndrome and Uterine Leiomyoma: A casecontrol study. The Nigerian Health Journal, 24(1). https://doi.org/10.60787/tnhj.v24i1.765 tnhjph.com

Alexander, K. G., Lee, SY. C., Haddad, C. N., & Tanos, V. (2024). Minimally invasive techniques in myomectomy and fertility outcomes: A narrative review of the current evidence. Clinical and Experimental Obstetrics & Gynecology, 51(7), 151. https://doi.org/10.31083/j.ceog5107151

Бакиева, М. Ш., Рустамова, Ш. Р., Рахмонов, Т. О., Шарипова, Н. Н., & Мухитдинова, Х. С. (2022). Гипотензивное действие алкалоида бензоилгетератизина на функциональную активность гладкомышечных клеток аорты крысы. AcademicResearchJournalImpactFactor, 7.

Samixovna, M. K. (2024). MORPHOLOGICAL DATA OF THE ORGANS OF HEMATOPOIESIS AND HEMATOPOIESIS. Лучшие интеллектуальные исследования, 14(5), 66-74.

Samixovna, M. K. (2024). Morphologic Changes in Red Blood Cells. ResearchJournalofTraumaandDisabilityStudies, 3(3), 178-186.

Samixovna, M. K. (2024). MORPHOLOGICAL FEATURES OF POSTPARTUM CHANGES IN UTERINE MEMBRANES. SCIENTIFIC JOURNAL OF APPLIED AND MEDICAL SCIENCES, 3(4), 277-283.

Samixovna, M. K. (2024). Current Data on Morphological and Functional Characteristics of the Thyroid Gland in Age Groups. JournalofScienceinMedicineandLife, 2(5), 77-83.

Samixovna, M. X. (2024). AYOL ORGANIZMI REPRODUKTIV ORGANLARINING RIVOJLANISH XUSUSIYATLARI. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 55(2), 113-121.

Samixovna, M. X. (2024). OITS KASALLIGI, TA'RIFI VA KASALLIKNING KELIB CHIQISH SABABLARI. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 55(2), 122-133.

Мухиддинова, Х. С. (2024). РАЗВИТИЕ ЯИЧНИКОВ, ИХ МОРФОЛОГИЯ И ОСОБЕННОСТИ ФУНКЦИОНИРОВАНИЕ. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 55(2), 134-141.

Мухитдинова, Х. С. (2024). СОВРЕМЕННЫЕ ВЗГЛЯДЫ НА РАЗВИТИЕ БАКТЕРИАЛЬНОГО ВАГИНОЗА У ЖЕНЩИН ФЕРТИЛЬНОГО ВОЗРАСТА. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 55(2), 97-103.

Мухитдинова, Х. С. (2024). ЗАБОЛЕВАЕМОСТЬ СПИДОМ, МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ БОЛЕЗНИ. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 55(2), 104-112.

Samikhovna, M. K. (2024). MODERN VIEWS ON ACROMEGALY AND IMMUNOMORPHOLOGY OF THIS DISEASE. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(10), 179-183.

Mukhitdinova, K. S. (2024). Clinical and Morphological Aspects of the Functioning of the Lymphatic System. International Journal of Alternative and Contemporary Therapy, 2(9), 101-106.

Samixovna, M. X. (2025). BACHADON BO ‘YNI RAKINING ZAMONAVIY TASHXISOTI VA PROFILAKTIKASI. Modern education and development, 19(3), 305-315.

Samixovna, M. X. (2024). BACHADON BO ‘YNINING KASALLIKLARDAGI KLINIKO-MORFOLOGIK AHAMIYATI. Modern education and development, 16(11), 73-84.

Samixovna, M. X. (2024). BACHADON ENDOMETRIYSINING HOMILADORLIK YUZAGA KELISHIDAGI AHAMIYATI. Modern education and development, 16(11), 51-61.

Samixovna, M. X. (2024). AYOLLARDA TUXUMDONLARDAGI SARIQ TANANING KLINIKO-MORFOLOGIK XUSUSIYATLARI. Modern education and development, 16(11), 131-142.

Мухитдинова, Х. С. (2024). КЛИНИКО-МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ЖЕЛТОГО ТЕЛА В ЯИЧНИКАХ У ЖЕНЩИН. Modern education and development, 16(11), 143-154.