This article provides an in-depth analysis of the hereditary factors of neurogenetic diseases, focusing on the genetic mechanisms, pathogenetic processes, and the role of heredity in the development of Parkinson’s disease. The paper examines modern advances in molecular genetics, genomic analysis methods, and genetic mutations that affect neurodegenerative processes. It presents evidence-based analytic conclusions about interactions among genes such as SNCA, LRRK2, PARK2, PINK1, and DJ-1 in the etiopathogenesis of Parkinson’s disease, their toxic effects on dopaminergic neurons, and their hereditary transmission characteristics.

The study also addresses how hereditary determinants are phenotypically expressed within a framework that includes the multifactorial nature of neurogenetic heredity, epigenetic modifications, mitochondrial dysfunction, and oxidative stress mechanisms.

Neurogenetics, heredity, Parkinson’s disease, gene mutation, dopaminergic neurons, epigenetics, multifactorial heredity, SNCA gene, LRRK2, genomic analysis, neurodegeneration, personalized medicine.Neurogenetics, heredity, Parkinson’s disease, gene mutation, dopaminergic neurons, epigenetics, multifactorial heredity, SNCA gene, LRRK2, genomic analysis, neurodegeneration, personalized medicine.

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