The study provides a comprehensive analysis of morphofunctional changes in human bone tissue under the influence of endogenous and exogenous factors. Bone tissue plays a central role in maintaining the structural and functional integrity of the musculoskeletal system. The research emphasizes that both internal mechanisms—such as genetic predisposition, hormonal regulation, and metabolic balance—and external influences, including environmental pollution, nutritional habits, and levels of physical activity, significantly affect bone density, structure, and strength. The methodological framework integrates bioimpedance analysis, osteodensitometry, and statistical modeling to assess correlations between influencing factors and bone morphofunctional dynamics. The results highlight the multifactorial nature of skeletal weakening and underscore the importance of individualized preventive and therapeutic strategies. The study contributes to the advancement of osteology by establishing a scientific foundation for developing targeted pharmacological and non-pharmacological interventions aimed at preserving bone health, preventing degenerative-dystrophic diseases, and improving life quality across diverse population groups.

Bone tissue, morphofunctional changes, endogenous factors, exogenous factors, osteoporosis, osteoarthritis, skeletal system, bone density, metabolism, environmental impact, preventive medicine, clinical pharmacology.

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