Articles | Open Access | https://doi.org/10.55640/

FEATURES OF COAGULATION HEMOSTASIS DISORDERS IN PREGNANT WOMEN: CURRENT CONCEPTS AND CLINICAL SIGNIFICANCE

Zaynutdinova D.L., Mirazizova N.M. , Tashkent State Medical University

Abstract

This article examines the clinical and laboratory characteristics of hemostatic disorders in pregnant women and current approaches to their management, based on an analysis of 50 scientific publications from the world literature published over the past five years.

Keywords

reproductive health, pregnancy, hemostasis, thrombocytopenia, thrombocytopathy, hypercoagulability, hypocoagulability, obstetric hemorrhage, maternal mortality.

References

American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics. ACOG Practice Bulletin No. 196: Thromboembolism in Pregnancy. Obstet Gynecol. 2018 Jul;132(1):e1-e17. doi: 10.1097/AOG.0000000000002706. Erratum in: Obstet Gynecol. 2018 Oct;132(4):1068. doi: 10.1097/AOG.0000000000002923. PMID: 29939938.

Davis S, Pandor A, Sampson FC, Hamilton J, Nelson-Piercy C, Hunt BJ, Daru J, Goodacre S, Carser R, Rooney G, Clowes M. Thromboprophylaxis during pregnancy and the puerperium: a systematic review and economic evaluation to estimate the value of future research. Health Technol Assess. 2024 Mar;28(9):1-176. doi: 10.3310/DFWT3873. PMID: 38476084; PMCID: PMC11017156.

Macrotrends / World Bank data - Uzbekistan maternal mortality rate (modelled estimate ~26/100,000, 2023)

Mangla A, Hamad H. Thrombocytopenia in Pregnancy. [Updated 2022 Nov 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.

Varrias D, Spanos M, Kokkinidis DG, Zoumpourlis P, Kalaitzopoulos DR. Venous Thromboembolism in Pregnancy: Challenges and Solutions. Vasc Health Risk Manag. 2023 Jul 20;19:469-484. doi: 10.2147/VHRM.S404537. PMID: 37492280; PMCID: PMC10364824.

WHO - Maternal mortality (fact sheet). 7 Apr 2025.

WHO - Postpartum haemorrhage (overview & roadmap). 11 Oct 2023.

WHO - Postpartum haemorrhage. 11 Oct 2023

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FEATURES OF COAGULATION HEMOSTASIS DISORDERS IN PREGNANT WOMEN: CURRENT CONCEPTS AND CLINICAL SIGNIFICANCE. (2025). International Journal of Medical Sciences, 5(11), 180-182. https://doi.org/10.55640/