This review synthesizes research on laboratory tests and genetic screening for diagnosing adolescent thrombocytopathy; novel therapies and treatment efficacy for managing adolescent thrombocytopathy to address diagnostic challenges arising from clinical heterogeneity and genetic complexity. The review aimed to evaluate current diagnostic techniques, benchmark integrated diagnostic algorithms, identify novel therapeutic approaches, compare thrombopoietin receptor agonists with alternative treatments, and analyze limitations in existing protocols. A systematic analysis of clinical, genetic, and therapeutic studies published up to mid-2024 was conducted, emphasizing next-generation sequencing and thrombopoietin receptor agonists in adolescent populations.

thrombocytopathy, diagnostics, NGS, genotype, phenotyping, algorithms, platelets

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