Neurocirculatory asthenia (NCA) is a common functional cardiovascular disorder observed in adolescents, characterized by autonomic dysfunction and psychosocial stress. This study aimed to investigate the clinical features, autonomic function, and psychological correlates of NCA in a cohort of 120 adolescents aged 12–18 years. Clinical evaluation, tilt-table testing, heart rate variability analysis, and standardized psychological assessments were conducted. Results showed a high prevalence of fatigue (85%), palpitations (78%), dizziness (65%), and exercise intolerance (54%). Autonomic dysfunction, including orthostatic hypotension/tachycardia and reduced parasympathetic activity, was observed in 57–68% of participants. Psychological assessment indicated elevated anxiety (62%) and depressive symptoms (35%), which were significantly correlated with autonomic abnormalities. Female adolescents exhibited slightly higher symptom prevalence compared to males. The findings emphasize the importance of a comprehensive biopsychosocial approach for early diagnosis and effective management of NCA in adolescents. Integrated interventions targeting both physiological and psychological aspects are essential for improving quality of life and long-term outcomes.

Neurocirculatory asthenia; Adolescents; Autonomic dysfunction; Fatigue; Palpitations; Anxiety; Depressive symptoms; Biopsychosocial approach

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