Long-term use of non-removable dental prostheses represents a significant clinical and biological factor influencing the anatomical and functional state of the oral cavity. Continuous interaction between prosthetic structures and oral tissues gradually alters biomechanical load distribution, mucosal integrity, periodontal conditions, and neuromuscular responses. This theoretical review article synthesizes findings from contemporary literature to provide a comprehensive analysis of how prolonged use of fixed prostheses affects hard and soft oral tissues, salivary parameters, occlusal dynamics, and oral motor function. The review highlights the mechanisms through which prosthetic materials, design quality, and oral hygiene practices influence tissue adaptation or deterioration. Special attention is given to morphological changes in the gingiva, alveolar bone remodeling, prosthesis-induced plaque retention, and shifts in occlusal function. Furthermore, the article discusses long-standing prosthetic-functional correlations, including muscle coordination, mastication efficiency, phonetics, and temporomandibular joint responses. The review emphasizes the importance of early detection of prosthesis-related complications through regular clinical examinations and functional assessment protocols. Ultimately, this paper underscores the need for evidence-based prosthodontic planning, maintenance strategies, and patient education to preserve optimal oral function over extended periods of prosthesis use.

fixed prostheses, oral cavity, long-term use, anatomy, function, occlusion, mucosa, adaptation, periodontium, biomechanics.

Boyd RL, Baumrind S. The effects of orthodontic treatment on periodontal status. Am J Orthod Dentofacial Orthop.

van der Weijden F, Slot DE. Oral hygiene in orthodontic patients: a systematic review. Am J Orthod Dentofacial Orthop.

Ergashev, B. (2025). Sirkon dioksid qoplamalari va materialining klinik laborator ahamiyati. Journal of Uzbekistan’s Development and Research (JUDR), 1(1), 627–632.

Ergashev, B. (2025). Gingivitning bakteriologik etiologiyasi va profilaktikasi. In International Scientific Conference: Innovative Trends in Science, Practise and Education, 1(1), 122–128.

Ergashev, B. (2025). Bemorlar psixologiyasi va muloqot ko‘nikmalari. Modern Science and Research, 4(2), 151–156.

Ergashev, B. (2025). Pulpitning etiologiyasi, patogenezi, morfologiyasi va klinik simptomlari. Modern Science and Research, 4(3), 829–838.

Ergashev, B. (2025). Stomatologiyada tish kariesi: Etiologiyasi, diagnostika va davolash usullari. Modern Science and Research, 4(3), 821–828.

Ergashev, B. (2025). Tish emal prizmalariga yopishib olgan tish blyashka matrixning mikrobiologiyasi va tarkibi. Modern Science and Research, 4(3), 815–820.

Ergashev, B. (2025). Advances in oral health: Prevention, treatment, and systemic implications. American Journal of Education and Learning, 3(3), 1108–1114.

Tursunaliyev, Z., & Ergashev, B. (2025). Bolalarda tish kariesini oldini olish usullari. Modern Science and Research, 4(4), 686–691.

Ergashev, B. (2025). Karies va paradont kasalliklari profilaktikasi. Modern Science and Research, 4(4), 732–741.

Ergashev, B. (2025). Psychological support for cancer patients. ИКРО журнал, 15(1), 164–167.

Ergashev, B., & Raxmonov, Sh. (2025). Oral trichomoniasis: Epidemiology, pathogenesis, and clinical significance. Kazakh Journal of Ecosystem Restoration and Biodiversity, 1(1), 19–27.

Ergashev, B., & Raxmonov, Sh. (2025). Transmission dynamics of tuberculosis. Kazakh Journal of Ecosystem Restoration and Biodiversity, 1(1), 28–35.

Ergashev, B. J. (2025). Uch shoxli nervning yallig‘lanishi. Research Focus, 4(3), 162–169.