Objective: The aim of this study is to determine optimal approaches to the treatment of various forms of glomerulonephritis (GN) in children based on an analysis of morbidity in the Andijan region. Methods: The study analyzed the clinical and laboratory characteristics, prevalence, and course of acute glomerulonephritis in 126 children treated at the Andijan Regional Children's Multidisciplinary Medical Center over a 10-year period. Diagnosis was verified based on anamnesis, extrarenal symptoms (edema, hypertension), and renal symptoms (hematuria, proteinuria). Results: A link between GN and previous infection was established in 90.8% of patients, with a confirmed streptococcal etiology in 64.5%. The disease manifested as typical acute nephritic syndrome in 69.1% of patients, while 22% presented with an atypical onset. Treatment involved a combination of antibiotics, anticoagulants (heparin), and antiplatelet agents. For patients with Nephrotic Syndrome (NS), corticosteroid therapy was the standard; however, due to high relapse rates and steroid resistance, cytostatics (such as 6-mercaptopurine) and pulse therapy were employed for optimizing outcomes. Additionally, specific therapeutic regimens were identified for hepatitis-associated nephritis (using interferons) and cases associated with tuberculosis infection.  Conclusion: The study indicates an increase in the number of patients with GN accompanied by nephrotic syndrome, hematuria, and hypertension. Effective management requires an individualized selection of basic therapy, including corticosteroids and cytostatics, as well as screening for hepatitis and tuberculosis to rule out secondary causes.

Acute glomerulonephritis, children, nephrotic syndrome, corticosteroids, cytostatics, hematuria, streptococcal infection, treatment optimization, Andijan region.

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