Chemotherapy of tuberculosis, especially multidrug-resistant forms, remains a complex task due to the development of adverse reactions (ADRs), which often lead to non-compliance with the treatment regimen, its discontinuation and, as a consequence, to the growth of drug resistance of Mycobacterium Tuberculosis . Second-line drugs are the most toxic. This review systematizes the main types of side effects of anti-tuberculosis drugs, examines the pathogenetic mechanisms of their development, and discusses modern approaches to prevention and treatment, including pharmacological and non-pharmacological methods.

tuberculosis, anti-tuberculosis drugs, side effects, hepatotoxicity, neurotoxicity, correction, drug resistance.

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