Background: Microbial eczema is a chronic inflammatory dermatosis closely linked to skin and gut dysbiosis. Emerging evidence regarding the "gut-skin axis" suggests that modulating the intestinal microbiota with probiotics and prebiotics (synbiotics) may influence skin inflammation and immune response to Staphylococcus aureus. Objective: To evaluate the clinical efficacy of adding a synbiotic supplement (containing Lactobacillus rhamnosus, Bifidobacterium longum, and Fructooligosaccharides) to the standard treatment regimen of microbial eczema. Methods: A randomized controlled clinical trial was conducted at Andijan State Medical Institute involving 90 patients with microbial eczema. Patients were divided into two groups: the Control Group (n=45) received standard topical and systemic therapy, while the Main Group (n=45) received standard therapy plus an oral synbiotic complex once daily for 30 days. Efficacy was assessed using the SCORAD index, Dermatology Life Quality Index (DLQI), and recurrence rates over a 6-month follow-up. Results: By day 30, the Main Group showed a significantly greater reduction in SCORAD scores (72% reduction) compared to the Control Group (55% reduction, p<0.05). Patients receiving synbiotics reported faster relief from pruritus and a marked improvement in DLQI. Furthermore, the recurrence rate at 6 months was significantly lower in the synbiotic group (22%) compared to the control group (48%). Conclusion: The inclusion of synbiotics in the treatment of microbial eczema enhances clinical response, accelerates symptom resolution, and reduces the frequency of relapses, likely by normalizing the gut-skin immune axis.

Microbial eczema, probiotics, prebiotics, synbiotics, gut-skin axis, Staphylococcus aureus, Andijan State Medical Institute.

Salem, I., Ramser, A., Isham, N., & Ghannoum, M. A. (2018). The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Frontiers in Microbiology, 9, 1459.

Sizova, L. A. (2022). Correction of intestinal dysbiosis in the complex treatment of microbial eczema. Dermatology and Venereology Journal, 34(2), 45-50.

Kim, J. E., Kim, H. S. (2014). Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies. Journal of Clinical Medicine, 3, 484-496.

Data from Andijan State Medical Institute, Department of Dermatology (2024). Internal Clinical Trial Report.

World Allergy Organization (WAO). (2023). Guideline on the use of probiotics in the management of allergic diseases.