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| Open Access |
https://doi.org/10.55640/
MODERN APPROACHES TO DIAGNOSING AND DIFFERENTIATING DRUG-RESISTANT TUBERCULOSIS
Djurabaeva Mukhabbat Khusanovna , Tashkent State Medical University, PhD, Associate Professor of Department Republican Specialized Scientific and Practical Medical Center for Phthisiology and Pulmonology, phthisiologist Tashkent, UzbekistanAbstract
Drug-resistant tuberculosis (DR-TB), including multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) forms, is a critical global health challenge. The field of diagnostics is rapidly evolving, moving away from slow, traditional culture methods toward fast, molecular techniques that can identify resistance within hours or days. This review explores the main diagnostic methods for DR-TB, highlighting their strengths, weaknesses, and role in clinical practice. It pays special attention to automated molecular platforms and next-generation sequencing (NGS), assessing their potential for widespread use.
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References
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Walker TM, Miott o P., Köser CU, et al. The 2021 WHO catalog of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis. Lancet Microbe . 2022.
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