This study aimed to evaluate the efficacy of micellar vitamin D (Aquadetrim) in correcting vitamin D deficiency in patients with chronic pancreatitis (CP) complicated by exocrine pancreatic insufficiency. A total of 34 patients were examined. Among them, 20 patients with serum vitamin D levels below 20 ng/mL were assigned to the main group and received micellar vitamin D supplementation for 3 months alongside baseline enzyme therapy. The remaining 14 patients received only enzyme therapy. The results showed that enzyme therapy alone partially increased vitamin D levels, whereas patients receiving micellar vitamin D achieved a significant increase in serum 25(OH)D, approaching normal values. Clinical symptoms, including abdominal pain, muscle cramps, fatigue, hair loss, and brittle nails, improved markedly in the main group. No increase in serum calcium levels was observed during therapy, indicating the safety of the preparation. These findings suggest that in patients with chronic pancreatitis, combining enzyme therapy with micellar vitamin D is an effective approach for correcting vitamin D deficiency.

Chronic pancreatitis; exocrine insufficiency; vitamin D deficiency; 25(OH)D; micellar vitamin D; Aquadetrim; enzyme therapy; pancreatin; malabsorption; clinical efficacy.

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