Hospital-acquired infections (HAIs) remain one of the most significant healthcare problems, significantly impacting morbidity, mortality, and the economic costs of healthcare facilities. This article presents a comparative review of national and global practices in the prevention and control of HAIs, focusing on current epidemiological trends, risk factors, and common etiologic agents. Particular attention is paid to an analytical study of the situation in Uzbekistan and a comparison with international standards, including recommendations from the WHO, CDC, and European Centers for Infection Control. Successful practices in developed countries, such as the introduction of care bundles, enhanced microbiological monitoring, and programs for the rational use of antibiotics, are analyzed. Based on the identified differences, key areas for improving infection control in healthcare facilities in Uzbekistan are identified. The review emphasizes the need for a comprehensive approach combining clinical, managerial, and educational measures to effectively reduce HAIs.

hospital-acquired infections, nosocomial infections, infection control, epidemiology, prevention, antibiotic resistance, microbiological monitoring, care-bundles, WHO standards, hospital.

World Health Organization. (2022). Global report on infection prevention and control. Geneva: WHO Press. https://www.who.int/publications/i/item/9789240051164

European Center for Disease Prevention and Control. (2023). Healthcare-associated infections: Annual epidemiological report for 2023. Stockholm: ECDC. https://www.ecdc.europa.eu/en/publications-data

Centers for Disease Control and Prevention. (2022). National and State Healthcare-Associated Infections Progress Report. Atlanta, GA: U.S. Department of Health and Human Services. https://www.cdc.gov/hai/data

Allegranzi, B., Bagheri Nejad, S., Combescure, C., Graafmans, W., Attar, H., Donaldson, L., & Pittet, D. (2011). Burden of endemic health-care-associated infection in developing countries: Systematic review and meta-analysis. The Lancet, 377(9761), 228–241. https://doi.org/10.1016/S0140-6736(10)61458-4

Mukhamadiev, N., Turaev, M., & Kholmuratova, D. (2020). Epidemiological characteristics of healthcare-associated infections in Uzbekistan: A regional analysis. Central Asian Journal of Medical Research, 6(2), 45–52.

Akhmadkhodzhaeva, M., and Kamoliddinova, S. (2025). DISTINCTIVE CLINICAL FEATURES OF HEPATITIS A IN ADOLESCENT GIRLS. Journal of Interdisciplinary Sciences and Innovations, 1(2), 425–428. Source: https://inlibrary.uz/index.php/jmsi/article/view/87336

INNOVATIVE METHODS OF CARDIOVASCULAR DISEASE PREVENTION. (2024). INTERNATIONAL CONFERENCE ON MULTIDISCIPLINARY STUDIES AND EDUCATION, 1(1), 22–23. https://eoconf.com/index.php/icmse/article/view/11

Akhmadkhodzhaeva, M. (2025). HYGIENE OF CHILDREN AND ADOLESCENTS: BIOLOGICAL PRINCIPLES OF ADAPTATION TO AGE-RELATED CHANGES. International Multidisciplinary Journal of Research and Development, 1(2), 72–78. Retrieved from https://inlibrary.uz/index.php/imjrd/article/view/73327

PREVENTION OF CHRONIC DISEASES IN THE URBAN ERA. (2024). INTERNATIONAL CONFERENCE ON MULTIDISCIPLINARY RESEARCH AND EDUCATION, 1(1), 28–29. https://eoconf.com/index.php/icmse/article/view/14

PREVENTION OF STUTTERING DISORDERS IN THE CONTEXT OF CLIMATE CHANGE. (2024). INTERNATIONAL CONFERENCE ON MULTIDISCIPLINARY RESEARCH AND EDUCATION, 1 (1), 16-17. https://eoconf.com/index.php/icmse/article/view/8

Akhmadkhodzhaeva M. M., Mirmukhamedov B. B. ANALYSIS AND ASSESSMENT OF THE QUALITY OF CHILDREN'S NUTRITION IN PRESCHOOL EDUCATIONAL INSTITUTIONS // Economy and Society. 2023. No. 11 (114)-1. URL: https://cyberleninka.ru/article/n/analiz-i-otsenka-kachestva-pitaniya-detey-v-doshkolno-obrazovatelnyh-uchrezhdeniyah.

Akhmadkhodzhaeva, M. M. "The impact of children's physical condition on their functional performance." (2023): 62-77.

Akhmadkhodzhaeva, M. M., Mirmukhamedov, B. B. The influence of children's physical condition on the body's functional performance // Economy and Society. - 2023. - No. 12 (115)-1. - P. 943-946.

Mirmukhamedov, B. B. SOCIAL AND PREVENTIVE MEASURES TO OPTIMIZING NUTRITION AND NUTRITIONAL STATUS OF CHILDREN AND ADOLESCENTS // Economy and Society. 2024. No. 2-1 (117). URL: https://cyberleninka.ru/article/n/sotsialno-profilakticheskie-meropriyatiya-po-optimizatsii-pitaniya-i-pischevogo-statusa-detey-i-podrostkov (date of access: 08.11.2025).

Mirmukhamedov B. B. HYGIENE OF THE ONLINE ENVIRONMENT: HOW SOCIAL NETWORKS INFLUENCE THE BEHAVIOR AND HEALTH OF ADOLESCENTS // Medical Journal of Young Scientists. - 2025. - No. 14 (06). - P. 148-151.

Mominov O. N. HYGIENIC ASSESSMENT: INFLUENCE OF GADGETS ON THE PHYSICAL DEVELOPMENT OF CHILDREN AND ADOLESCENTS // Medical Journal of Young Scientists. – 2025. – No. 14 (06). – P. 152-156.

Khalmirzaeva S. S. et al. PREVENTIVE MEDICINE AND SUSTAINABLE DEVELOPMENT: INTERRELATIONSHIP AND IMPACT // INTERNATIONAL CONFERENCE ON MULTIDISCIPLINARY STUDIES AND EDUCATION. – 2024. – Vol. 1. – No. 1. – P. 24-25.

Akhmadzhonov Sh. Sh. OCCUPATIONAL RISKS IN THE METALLURGICAL INDUSTRY AND THEIR IMPACT ON THE WORKERS' BODY // ORIENTAL JOURNAL OF MEDICINE AND NATURAL SCIENCES. – 2025. – Vol. 2. – No. 1. – P. 55-61.

Rustamova Sh. K. ELECTRONIC CIGARETTES AND AIR POLLUTION IN PUBLIC PLACES: A NEW SANITARY-HYGIENIC PROBLEM // Medical Journal of Young Scientists. – 2025. – No. 14 (06). – P. 181-185.

Mominov O. N. et al. THE ROLE OF DIGITAL TECHNOLOGIES IN MONITORING AND MANAGEMENT OF PUBLIC HEALTH // INTERNATIONAL CONFERENCE ON MULTIDISCIPLINARY STUDIES AND EDUCATION. – 2024. – Vol. 1. – No. 1. – P. 18-19.