This case series, titled "Bridging Hope: Alteplase Thrombolysis in Acute Ischemic Stroke – Insights from a Tertiary Care Centre in Bangladesh," presents a comprehensive examination of the application and outcomes of Alteplase thrombolysis in the management of acute ischemic stroke at a prominent tertiary care center in Bangladesh. The study encompasses a series of cases, detailing patient demographics, clinical characteristics, treatment protocols, and post-thrombolysis outcomes. Through a meticulous analysis of these cases, the abstract provides valuable insights into the feasibility, safety, and efficacy of Alteplase thrombolysis in the context of acute ischemic stroke management in Bangladesh.