Diseased vascular smooth muscles represent a significant challenge in modern medicine, often leading to complications such as hypertension, atherosclerosis, and vascular stenosis. However, recent research has unveiled promising therapeutic avenues through chemical interactions that can restore health and functionality to these compromised tissues. This paper explores the diverse array of chemical compounds and their interactions that show potential in mitigating vascular smooth muscle pathologies. From small molecules to complex peptides, understanding the mechanisms underlying these interactions provides a foundation for developing targeted therapies. By unlocking the therapeutic potential of chemical interventions, we aim to pave the way for innovative treatments that improve the prognosis and quality of life for individuals affected by vascular smooth muscle diseases.