Articles
| Open Access | OPTIMIZING FISCHER ESTERIFICATION OF SUBSTITUTED BENZOIC ACID WITH SEALED-VESSEL MICROWAVE CONDITIONS
Shafida Abdul Rahim , School of Pharmaceutical Sciences, University Sains Malaysia, Pulau Pinang, MalaysiaAbstract
Fischer esterification is a fundamental chemical transformation, widely used in organic synthesis for the preparation of esters. In this study, we present an optimized approach for Fischer esterification, specifically focusing on substituted benzoic acid derivatives, under sealed-vessel microwave conditions. By systematically varying reaction parameters such as temperature, catalyst, and reaction time, we achieved enhanced yields and reduced reaction times compared to conventional methods. Our results provide valuable insights into the efficient synthesis of esters from substituted benzoic acids, offering potential applications in pharmaceuticals, fragrances, and fine chemicals.
Keywords
Fischer esterification, Substituted benzoic acid, Sealed-vessel microwave, Organic synthesis, Ester synthesis, Reaction optimization
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