The food industry actively uses various types of dyes, classified as synthetic and natural. Synthetic dyes, which are artificially created organic compounds, are not usually found in the natural environment. Their production is often carried out in the form of granules or powders, which are easily dissolved in an aqueous environment .

Unlike synthetic dyes, natural dyes are made exclusively from natural sources. These natural substances not only color foods, but also enrich them with biologically active elements and nutrients, increasing their nutritional value. However, natural dyes are susceptible to deterioration under the influence of high temperatures and air, which requires manufacturers to pay special attention to their storage conditions.

The problem of using food dyes in nanoforms, such as titanium dioxide (E171), iron oxides (E172), as well as metallic dyes based on silver (E174) and gold (E175), is becoming increasingly relevant and requires additional study. Nanoparticles have properties that can differ significantly from the properties of larger particles of the same substances, which creates the need for an in-depth analysis of their impact on human health .

In Uzbekistan, as well as at the international level, accepted methods for controlling the quality and safety of food coloring additives must meet standards that ensure the reliability of research results.

food additive, food safety, nanoscale, nanomaterial, titanium dioxide, toxicity

Azimova Z.S. (2022) The effect of food dyes on the development of kidney diseases in children/ Вarqarorlik va еtakchi tadqiqotlar onlayn ilmiy jurnali №2(12),652-658

Azimova Z.S., (2023) Morphological Parameters of Rats After the Introduction of Titanium Dioxide (TiО2) Nanoparticles. Journal of healthcare and life-science, №2(3),34-38

Azimova, Z. S. (2022). Side Effects of Dietary Supplement E-171 (Titanium Dioxide) Associated with the Specific Toxicity of the Particles to the Body. Research Journal of Trauma and Disability Studies,2022, №1(9), 60-66.

Bahadar H., Maqbool F., Niaz K. et al. Toxicity of Nanoparticles and an Overview of Current Experimental Models // Iranian Biomedical Journal. 2016. N 20 (1). P. 1-11.

Bettini S, Boutet-Robinet E, Cartier C, Coméra C, Gaultier E, Dupuy J, Naud N, Taché S, Grysan P, Reguer S, Thieriet N, Réfrégiers M, Thiaudière D, Cravedi JP, Carrière M, Audinot JN, Pierre FH, Guzylack-Piriou L, Houdeau E. Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Sci Rep. 2017 Jan 20; 7:40373. doi: 10.1038/srep40373. PMID: 28106049; PMCID: PMC5247795.

Jovanovrc B. Critical review of public health regulations of titanium dioxide, a human food additive // Integrated environmental assessment and management. - 2014. - Vol. 11, № 1. - P. 10-20.

Lee D., Fanucchi M. V., Plopper C. G., Fung J., Wexler A.S. Pulmonary architecture in the conducting regions of six rats // Anat. Rec. (Hoboken). 2008. Vol.291, №8. P.916-926.

Mohamed H.R. Estimation of TiO2 nanoparticle-induced genotoxicity persistence and possible chronic gastritis-induction in mice // Food Chem. Toxicol. - 2015. - Vol. 83. - P. 76-83.

Азимова З.С. (2024), Морфофункциональные особенности легких под влиянием красителей, применяемых в пищевой промышленности, и их фитокоррекция .Фундаментал ва клиник тиббиёт ахборотномаси № 4 (10),265-266

Азимова З.С., Хасанова Д.А (2024) Xарактеристика побочного эффекта пищевой добавки Е-171(титан диоксид) и её связь с специфической токсичностью для организма (обзор литературы) Тиббиётда янги кун №8 (70),(23-27)

Бессонов В.В., Передеряев О.И., Богачук М.Н., and Малинкин А.Д.. "Пищевые красители в современной индустрии пищи – безопасность и контроль" Пищевая промышленность, no. 12, 2012, pp. 20-24.

ГОСТ Р 52671-2006. Продукты пищевые. Методы идентификации и определения массовой доли синтетических красителей в карамели. -М.: Стандартинформ, 2007. – 23-52 с.

Н. А. Тюмина. "Количественные характеристики популяции реснитчатых эпителиоцитов бронхов крыс в процессе формирования дефинитивной структуры легких" Вестник новых медицинских технологий. Электронное издание, vol. 12, no. 5, 2018, pp. 259-263.

Самсонова М. В., Черняев А. Л. Гистологическая дифференциальная диагностика гранулематозных болезней легких (часть I) //Архив патологии. – 2019. – Т. 81. – №. 1. – С. 65-70.

Тутельян В. А. и др. Оптимальное питание-основа здорового образа жизни //Здоровье молодежи: новые вызовы и перспективы. – 2019. – С. 228-249.

Шурлыгина, А. В., et al. "Влияние комплекса мелатонина, оксида алюминия и полиметилсилоксана на клеточный состав селезёнки мышей, содержавшихся в условиях круглосуточного освещения." Acta Biomedica Scientifica 6.4 (2021): 252-264.