Sebaceous glands (SGs) are lipid-producing mini-organs of the skin, typically forming part of the pilosebaceous unit together with the hair follicle and its duct. Their histogenesis depends on tightly timed epithelial–mesenchymal interactions and a balance of morphogenetic signaling pathways that govern lineage choice, proliferation, and terminal sebocyte differentiation. This article reviews major factors that influence SG histogenesis across prenatal development, postnatal maturation, and remodeling in later life. Key determinants include canonical Wnt/β-catenin activity that biases epidermal progenitors toward hair follicle versus sebaceous lineages, Hedgehog signaling that supports proliferation and duct/sebocyte programing, and transcriptional regulators that coordinate fate decisions and lipid metabolic maturation. Progenitor pool dynamics—exemplified by Blimp1/PRDM1-associated populations—and the c-MYC network further shape gland size and renewal, while endocrine cues (especially androgens) modulate differentiation trajectories through androgen receptor–dependent programs that intersect with stress pathways such as p53.

sebaceous gland, histogenesis, pilosebaceous unit, Wnt/β-catenin, Hedgehog, Blimp1/PRDM1, c-MYC, androgen receptor.

Niemann C., Horsley V. Development and homeostasis of the sebaceous gland // Seminars in Cell & Developmental Biology. — 2012. — Vol. 23, No. 8. — P. 928–936. — DOI: 10.1016/j.semcdb.2012.08.010.

Niemann C. Differentiation of the sebaceous gland // Dermatoendocrinology. — 2009. — Vol. 1, No. 2. — P. 64–67. — DOI: 10.4161/derm.1.2.8486.

Horsley V., O’Carroll D., Tooze R., Ohinata Y., Saitou M., Obukhanych T., Nussenzweig M., Tarakhovsky A., Fuchs E. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland // Cell. — 2006. — Vol. 126, No. 3. — P. 597–609. — DOI: 10.1016/j.cell.2006.06.048.

Cottle D. L., Kretzschmar K., Schweiger P. J., et al. c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis // Cell Reports. — 2013. — Vol. 3, No. 2. — P. 427–441. — DOI: 10.1016/j.celrep.2013.01.013.

Lim X., Nusse R. Wnt Signaling in Skin Development, Homeostasis, and Disease // Cold Spring Harbor Perspectives in Biology. — 2013. — Vol. 5, No. 2. — a008029. — DOI: 10.1101/cshperspect.a008029.