Modern bioactive restorative materials represent a significant advancement in restorative dentistry, aiming not only to replace lost tooth structure but also to actively interact with the surrounding dental tissues. This article reviews and analyzes the clinical efficacy of contemporary bioactive restorative materials, including bioactive glass–based composites, giomers, resin-modified glass ionomer cements, and calcium silicate–based materials. Emphasis is placed on their ability to promote remineralization, release therapeutic ions (such as calcium, phosphate, and fluoride), inhibit secondary caries, and enhance marginal integrity. Clinical outcomes related to longevity, wear resistance, biocompatibility, postoperative sensitivity, and patient-centered success rates are critically evaluated based on recent clinical trials and systematic reviews. The findings indicate that modern bioactive materials demonstrate comparable or superior clinical performance to conventional restorative materials, particularly in high-caries-risk patients and minimally invasive treatment approaches. However, long-term randomized controlled studies are still required to establish standardized clinical protocols and to fully assess their durability under functional oral conditions.

Bioactive restorative materials; Clinical efficacy; Remineralization; Secondary caries prevention; Ion release; Minimally invasive dentistry

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