An increase in the level of follicle-stimulating hormone (FSH) in women of reproductive age is one of the key markers of decreased ovarian reserve and a harbinger of reproductive failure. The article discusses the pathophysiological mechanisms of increased FSH, its diagnostic value and clinical significance in the context of infertility. The article presents the results of the analysis of data from 152 patients with varying degrees of increased FSH, and studies possible causes (age-related changes, iatrogenic interventions, autoimmune processes, genetic predisposition) and potential approaches to treatment. Modern strategies for patient management are covered, including the use of hormone replacement therapy, an individualized ovarian stimulation protocol, the use of donor oocytes, as well as innovative methods using growth factors and stem cells. Emphasis is placed on the need for a differentiated approach and careful assessment of the ovarian reserve in clinical practice.

Follicle stimulating hormone, FSH, infertility, ovarian reserve, AMH, hormonal therapy, donor eggs, IVF, premature ovarian failure, decreased fertility

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