Protein folding is a crucial biological process, and its errors, known as misfolding, are linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This study examines the biophysical mechanisms of folding and misfolding, integrating experimental data and computational modeling to analyze protein stability and aggregation. Therapeutic approaches, including molecular chaperones and small-molecule interventions, are also explored. The findings highlight the importance of understanding protein dynamics for disease prevention and the development of targeted treatments.

protein folding, protein misfolding, neurodegenerative diseases, biophysics, molecular dynamics, therapeutic interventions.

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