Presents the results of treatment of patients with TB of the peripheral lymph nodes. Lymphotropic administration of isoniazid for one month on a background of standard TB treatment leads to a rapid clinical benefit, which developed against the background of significant reduction in immune status and persisted until the end of the observation with the manifestation of the change in the ratio in the number of subpopulations of T–lymphocytes. Thus, compared with the control group, the experimental group of patients within a month after the start of lymphotropic therapy appeared stable positive clinical and laboratory dynamics, which gradually increased until the end of follow–up. However, it should be noted that the positive clinical effect was developed against the backdrop of significant low immune siatusa, which lasted until the end of the observation and manifest change in the ratio in the number of subpopulation of T–lymphocytes (CD4+ и CD8+ cell). Since the role of intercellular mediators that regulate the immune response in the body perform cytokines, the existens of an imbalance in tuberculosis of peripheral lymph nodes was one pathophysiological basis, which is the development and progression of specific inflammation. Comparative observation in experimental and control group showed that the targeted delivery of isoniazid at lymphotropic therapy has a positive effect on the dynamics of local inflammation: in patients of the experimental group was noted faster resorption local inflammatory changes and in any case was not observed in the control, development of fluctuations in the lymph nodes. The latter may have been due to the cytokine imbalance that patients in the control group had not normalized until the end of treatment. Patients test group, by contrast, the quantity of cytokines in the treatment normalized by IL–1β and FNOα, while the content of IFNγ and IL–2 remains significantly below normal.

lymphatic system, extrapulmonary tuberculosis, lymphotropic administration isoniazid, tuberculosis of peripheral lymph nodes, treatment tuberculosis, immune status, cytokines, CD4+ / CD8+.

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