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| Open Access | MECHANISMS OF IONIZING RADIATION-INDUCED DAMAGE TO CELLS AND DNA
Kholmetov Shavkat Sherimatovich, Fayziyeva Nodira Alisherovna , Tashkent State Technical University Department of Biomedical Engineering, Biophysics and Informatics Assistant: Orazbaev Nuraliy Amanaliyevich, Rustamov Sanjar Rustam ugli , 2nd Faculty of General Medicine, 1st-year student Kudaibergenov Sultan Polatovich , Pediatrics Program, 1st-year studentAbstract
This article analyzes the primary physical and biological effects of ionizing radiation on living cells. Radiation-induced DNA damage, disruption of cellular structures, and the mechanisms of their repair are explained based on scientific evidence. Additionally, risk factors associated with the use of radiation sources in medical practice and the main methods of radiation protection aimed at minimizing these risks are discussed. The results hold practical significance in the fields of biophysics, radiobiology, and medical diagnostics.
Keywords
Ionizing radiation, radiobiological effects, DNA damage, cellular processes, radiation dose, safety standards, X-ray, radiotherapy, mutagenesis, ionization process.
References
Hall, E. J., & Giaccia, A. J. (2018). Radiobiology for the Radiologist (8th ed.). Philadelphia: Wolters Kluwer.
Turner, J. E. (2007). Atoms, Radiation, and Radiation Protection (3rd ed.). Weinheim: Wiley-VCH.
Khan, F. M., & Gibbons, J. P. (2014). The Physics of Radiation Therapy (5th ed.). Philadelphia: Lippincott Williams & Wilkins.
International Commission on Radiological Protection (ICRP). (2007). The 2007 Recommendations of the ICRP. ICRP Publication 103.
UNSCEAR (2008). Sources and Effects of Ionizing Radiation. United Nations.
Alberts, B., Johnson, A., Lewis, J., et al. (2015). Molecular Biology of the Cell (6th ed.). New York: Garland Science.
Paganetti, H. (2012). Proton Therapy Physics. Boca Raton: CRC Press.
Lindahl, T., Modrich, P., & Sancar, A. (2000). DNA repair mechanisms. Science.
Sacher, E. (2017). Radiation Effects on Cells and Tissues. Springer, Cham.
Hall, E. J., & Giaccia, A. J. (2012). Radiobiology for the Radiologist (7th ed.). Philadelphia: Lippincott Williams & Wilkins.
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