Articles
| Open Access | PSEUDOALLERGY IN MODERN MEDICINE: A GROWING GLOBAL PROBLEM AMONG THE POPULATION
Saidova Firuza Salomovna¹, Habibullayeva Mohitobon Ismoilxonovna², Rasulova Raykhona Sayfulla kizi³ , ¹Assistant, Department of Pathophysiology, Samarkand State Medical University ²Student, Faculty of Medicine, Samarkand State Medical University ³Student, Faculty of Medicine, Samarkand State Medical UniversityAbstract
In this article, the clinical, pathogenetic, and molecular bases of pseudoallergy are analyzed. Pseudoallergy is a clinically allergylike condition occurring without the involvement of immunoglobulin E (IgE), primarily resulting from direct stimulation of mast cells and basophils. The article details key mechanisms of pseudoallergy: mast cell degranulation, mediator (histamine, serotonin, tryptase) release, and their effects on body systems. In addition, biomarkers distinguishing true allergy from pseudoallergy, experimental approaches for diagnosis (provocation tests, measurement of mediator levels, evaluation of mast cell inhibition), and their diagnostic significance are discussed. This work aims to clarify the clinical and laboratory features of pseudoallergy, and to lay a scientific foundation for developing new therapeutic strategies.
Keywords
pseudoallergy; mast cells; histamine; serotonin; tryptase; degranulation; IgE independent reaction; biomarkers; experimental approaches; pathogenesis.
References
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