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| Open Access | STUDY AND DETERMINATION OF THE SENSITIVITY OF MICROORGANISMS TO CHEMOTHERAPEUTIC DRUGS AND ANTIBIOTICS
Saodat Ahmedova , Teacher of Microbiology, Immunology, and Virology at the Termez Branch of Tashkent State Medical University Ruxshona Abrayqulova , Student of the Termez Branch of Tashkent State Medical UniversityAbstract
This article provides a scientific analysis of the mechanisms of action of chemotherapeutic agents and antibiotics on microbial activity, as well as the methods used to determine their sensitivity. The excessive or improper use of antibiotics has led to an increase in resistant forms of microorganisms. Therefore, assessing microbial sensitivity to antibiotics is of great clinical importance for the correct treatment of infections, the rational selection of drugs, and the prevention of drug-resistant strains. The article discusses both theoretical and practical aspects of methods such as disk diffusion, minimum inhibitory concentration (MIC), and the automated VITEK system.
Keywords
antibiotic, chemotherapy, microorganisms, sensitivity, MIC, disk diffusion, VITEK system.
References
Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. 2023.
EUCAST Guidelines for Antimicrobial Susceptibility Testing, Version 13.0, 2023.
Todar K. Antimicrobial Agents: Mechanisms of Action and Resistance. University of Wisconsin, 2020.
Cheesbrough M. Medical Laboratory Manual for Tropical Countries. Cambridge University Press, 2019.
Jawetz, Melnick & Adelberg. Medical Microbiology. 28th Ed. McGraw-Hill, 2021.
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This work is licensed under a Creative Commons Attribution 4.0 International License.